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CIALIS for Once Daily Use for Erectile Dysfunction. The recommended starting dose of CIALIS for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The CIALIS dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability. A follow-up, randomized, open-label cross-over trial by McMahon46 compared 12 weeks of tadalafil dose (10 mg daily vs 20 mg on-demand) in 145 men cialis dosage vs viagra tadalafilise A follow-up, randomized, open-label cross-over trial by McMahon46 compared 12 weeks of tadalafil dose (10 mg daily vs 20 mg on-demand) in 145 men with ED of at least 6 months duration and SEP3 Do not break or split a Cialis tablet. Swallow it whole. For erectile dysfunction, take Cialis just before sexual activity but not more than once per day. It can be used up to 36 hours before sexual activity. Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. With Viagra, there is a higher risk of vision changes than with Cialis. Among people who take Viagra or sildenafil, 3% get blue vision that lasts a few hours. On the other hand, Cialis has a slightly higher risk of muscle pain than Viagra and vardenafil.